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jnj 7706621  (MedChemExpress)


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    MedChemExpress jnj 7706621
    ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. <t>JNJ-7706621,</t> p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .
    Jnj 7706621, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Images

    1) Product Images from "Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice"

    Article Title: Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice

    Journal: EMBO Molecular Medicine

    doi: 10.1038/s44321-025-00335-y

    ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .
    Figure Legend Snippet: ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .

    Techniques Used: Gene Expression, RNA Sequencing, Western Blot, Positive Control, Expressing, Control



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    ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. <t>JNJ-7706621,</t> p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .
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    ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. <t>JNJ-7706621,</t> p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .
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    ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. <t>JNJ-7706621,</t> p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .
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    ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .

    Journal: EMBO Molecular Medicine

    Article Title: Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice

    doi: 10.1038/s44321-025-00335-y

    Figure Lengend Snippet: ( A ) Workflow diagram illustrating the process of obtaining thermogenic gene expression profiles associated with browning promotion from RNA-seq data in the GEO database, followed by the use of the CMap database to screen for small molecule compounds that promote browning. ( B ) Heatmap of the top 100 upregulated genes from four RNA-seq datasets. The remaining 100 genes are listed in Table . ( C ) Venn diagram of the four small molecule compound sets identified. ( D ) Representative immunoblot of Ucp1 protein in primary inguinal adipocytes treated with ten candidate small molecule compounds. Rosiglitazone is used as a positive control for adipose browning promotion. ( E ) Relative mRNA expression levels of Ucp1 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9610; Control vs. AT-7519, p = 0.0015; Control vs. BMS-345541, p = 0.9888; Control vs. CGP-60474, p = 0.9994; Control vs. ER-27319, p < 0.0001; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0170; Control vs. Daunorubicin, p = 0.0004; Control vs. Isomerazin, p < 0.0001; Control vs. Pirarubicin, p < 0.0001. ( F ) Relative mRNA expression levels of Fabp4 in primary inguinal adipocytes treated with ten candidate small molecule compounds ( n = 3). Control vs. AS-601245, p = 0.9974; Control vs. AT-7519, p = 0.0017; Control vs. BMS-345541, p = 0.9975; Control vs. CGP-60474, p = 0.0002; Control vs. ER-27319, p = 0.0005; Control vs. JNJ-7706621, p < 0.0001; Control vs. Alvocidib, p = 0.0032; Control vs. Daunorubicin, p < 0.0001; Control vs. Isomerazin, p = 0.9995; Control vs. Pirarubicin, p < 0.0001. n presents biological replicates. Data are presented as mean ± SEM. Statistical test: one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistical significance is indicated as follows: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns indicates no significant difference. .

    Article Snippet: JNJ-7706621 , MedChemExpress , HY-10329.

    Techniques: Gene Expression, RNA Sequencing, Western Blot, Positive Control, Expressing, Control